Contributors -- Acknowledgments -- Preface -- Part 1: Cardiovascular Disease: Past, Present, And Future -- 1: History of the heart / Mark E Silverman and Charles F Wooley -- 2: Burden of increasing worldwide cardiovascular disease / Ramachandran S Vasan, Emelia J Benjamin, Lisa M Sullivan, and Ralph B D'Agostino -- Part 2: Foundations Of Cardiovascular Medicine -- 3: Functional anatomy of the heart / Joseph F Malouf, William D Edwards, A Jamil Tajik, and James B Seward -- 4: Normal physiology of the cardiovascular system / Brian D Hoit and Richard A Walsh -- 5: Principles of molecular cardiology / Robert Roberts -- 6: Molecular and cellular biology of the normal, hypertrophied, and failing heart / Allen M Samarel and Richard Walsh -- 7: Biology of the vessel wall / Kathy K Griendling, David G Harrison, and R Wayne Alexander -- 8: Molecular development of the heart / Neeru Kaushik, Andy Wessels, Roger R Markwald, and Bradley B Keller-- 9: Genetic basis for cardiovascular disease / Robert Roberts and Elizabeth McNally -- 10: Tissue regeneration of the cardiovascular system and stem cells / Arjun Deb, Helmut Drexler, and Victor Dzau -- Part 3: Evaluation Of The Patient -- 11: Clinical practice guidelines in cardiovascular disease / Ira S Nash -- 12: History, physical examination, and cardiac auscultation / Robert A O'Rourke, James A shaver, and Mark E Silverman -- 13: Resting electrocardiogram / Agustin Castellanos, Alberto Interian Jr, and Robert J Myerburg -- 14: ECG exercise testing / Gregory Engel and Victor F Froelicher -- 15: Cardiac roentgenography / Robert A O'Rourke and Robert C Gilkeson -- 16: Echocardiography / Anthony N DeMaria and Daniel G Blanchard -- 17: Cardiac catheterization, cardiac angiography, and coronary blood flow and pressure measurements / Morton J Kern and Spencer B King III -- 18: Coronary intravascular ultrasound imaging / E Murat Tuzcu, Stephen J Nicholls, and Steven E Nissen -- 19: Nuclear cardiology / Daniel S Berman, Rory Hachamovitch, Leslee J Show, Sean W Hayes, and Guido Germano -- 20: Computed tomography of the heart / Matthew J Budoff, Michael Poon, and Guiseppe Mailolino -- 21: Magnetic resonance imaging of the heart / Han W Kim, Wolfgang G Rehwald, James A White, and Raymond J Kim -- 22: Magnetic resonance imaging and computed tomography of the vascular system / Jean-Christophe Cornilly, Valentin Fuster, and Zahi A Fayad -- 23: Positron emission tomography for the noninvasive study and quantitation of myocardial blood flow and metabolism in cardiovascular disease / Heinrich R Schelbert -- Part 4: Heart Failure -- 24: Pathophysiology of heart failure / Gary S Francis, Edward H Sonnenblick, W H Wilson Tang, and Philip Poole-Wilson -- 25: Epidemiology and diagnosis of heart failure / Owais Dar and Martin R Cowie -- 26: Diagnosis and management of heart failure / William T Abraham, Ayesha Hasan, and Philip Poole-Wilson -- 27: Surgical treatment of heart failure, cardiac transplantation, and mechanical ventricular support / Michael X Pham, Jonathan M Chen, Gerald J Berry, Eric A Rose, and John S Schroeder -- Part 5: Cardiomyopathy And Specific Heart Muscle Diseases -- 28: Classification of cardiomyopathies / Barry J Maron and Gaetano Thiene -- 29: Dilated cardiomyopathies / Luisa Mestroni, Edward M Gilbert, Brian D Lowes, and Michael R Bristow -- 30: Hypertrophic cardiomyopathy / Steve R Ommen, Rick A Nishimura, and A Jamil Tajik -- 31: Restrictive, obliterative, and infiltrative cardiomyopathies / Brian D Hoit and Sanjaya Gupta -- 32: Myocarditis and specific cardiomyopathies / Sean P Pinney and Donna M Mancini -- Part 6: Rhythm And Conduction Disorders -- 33: Genetics of channelopathies and clinical implications / Silvia G Priori and Carlo Napolitano -- 34: Anatomy of electrophysiology / Siew Yen Ho and Anton E Becker -- 35: Mechanisms of cardiac arrhythmias and conduction disturbances / Charles Antzelevitch -- 36: Approach to the patient with cardiac arrhythmias / Eric N Prystowsky and Richard I Fogel -- 37: Atrial fibrillation, atrial flutter, and atrial tachycardia / Eric N Prystowsky and Albert L Waldo -- 38: Supraventricular tachycardia: AV nodal reentry and Wolf-Parkinson-White Syndrome / Hugh Calkins --

39: Ventricular arrhythmias / Robert W Rho and Richard L Page -- 40: Bradyarrhythmias and pacemakers / Pugazhendhi Vijayaraman and Kenneth A Ellenbogen -- 41: Long-term continuous electrocardiographic recording / Eric N Prystowsky and Benzy J Padanilam -- 42: Techniques of electrophysiologic evaluation / Masood Akhtar -- 43: Antiarrhythmic drugs / Peter R Kowey, Gan-Xin Yan, and Harry Crijns -- 44: Treatment of cardiac arrhythmias with catheter-ablative techniques / Usha B Tedrow and William G Stevenson -- 45: Indications and techniques of electrical defibrillation and cardioversion / Richard E Kerber -- 46: Implantable cardioverter defibrillator / Christian Wolpert and Martin Borggrefe -- 47: Pediatric arrhythmias / Ronald J Kanter and Timothy Knilans -- Part 7: Syncope, Sudden Death, And Cardiopulmonary Resuscitation -- 48: Diagnosis and management of syncope / Mark D Carlson and Blair P Grubb -- 49: Sudden cardiac death / Matthew R Reynolds, Duane S Pinto, and Mark E Josephson -- 50: Cardiopulmonary and cardiocerebral resuscitation / Gordon A Ewy -- Part 8: Coronary Heart Disease -- Section 1: Pathophysiology And Prevention Of Coronary Heart Disease -- 51: Preventive strategies for coronary heart disease / David J Maron, Paul M Ridker, Scott M Grundy, and Thomas A Pearson -- 52: Atherothrombosis: role of inflammation / Prediman K Shah, Erling Falk, and Valentin Fuster -- 53: Coronary thrombosis: local and systemic factors / Juan Jose Badimon, Borja Ibanez, Valentin Fuster, and Lina Badimon -- 54: Coronary blood flow and myocardial ischemia / Christophe Depre, Stephen F Vatner, and Garrett J Gross -- 55: Nonatherosclerotic coronary heart disease / Bruce F Waller -- 56: Definitions of acute coronary syndromes / Michael C Kim, Annapoorna S Kini, and Valentin Fuster -- 57: Pathology of myocardial ischemia, infarction, reperfusion, and sudden death / Allen P Burke and Renu Virmani -- 58: Molecular and cellular mechanisms of myocardial ischemia-reperfusion injury / Cyril Ruwende, Scott Visovatti, and David J Pinsky -- Section 2: Clinical Presentation, Diagnosis, Evaluation, And Management -- 59: Unstable angina and non-ST-segment elevation myocardial infarction / Jame A de Lemos and Robert A O'Rourke -- 60: ST-segment elevation myocardial infarction / Eric H Yang, Bernard J Gersh, and Robert A O'Rourke -- 61: Pharmacologic therapy for acute coronary syndromes / Santo Dellegrottaglie, Antony H Gershlick, Massimo Chiariello, and Bernard J Gersh -- 62: Percutaneous coronary intervention / John S Douglas, Jr, and Spencer B King III -- 63: Mechanical interventions in acute myocardial infarction / Bruce R Brodie and William W O'Neill -- 64: Diagnosis and management of patients with chronic ischemic heart disease / Robert A O'Rourke, Patrick T O'Gara, Leslee J Shaw, and John S Douglas, Jr -- 65: Coronary bypass surgery / Joseph F Sabik, 3rd and Bruce W Lytle -- 66: Management of the patient after cardiac surgery / Douglas C Morris, Stephen D Clements, Jr, and John Pepper -- 67: Rehabilitation of the patient with coronary heart disease / Ian Graham, Shirley Ingram, Noeleen Fallon, Tora Leong, John Gormley, Veronica O'Doherty, Vincent Maher, and Suzanne Benson -- Part 9: Systemic Arterial Hypertension -- 68: Epidemiology of hypertension / Thomas G Pickering, and Gbenga Ogedegbe -- 69: Pathophysiology of hypertension / John E Hall, Joey P Granger, Michael E Hall, and Daniel W Jones -- 70: Diagnosis and treatment of hypertension / Arash Rashidi, Mahboob Rahman, and Jackson T Wright, Jr -- Part 10: Cardiopulmonary Disease -- 71: Pulmonary hypertension / Lewis J Rubin -- 72: Pulmonary embolism / Peter F Fedullo -- 73: Chronic Cor Pulmonale / E Clinton Lawrence and Kenneth L Brigham -- Part 11: Valvular Heart Disease -- 74: Acute rheumatic fever / Bongani M Mayosi and Jonathan R Carapetis -- 75: Aortic valve disease / Shahbudin H Rahimtoola -- 76: Mitral valve regurgitation including the mitral valve prolapse syndrome / Robert A O'Rourke and Louis J Dell'Italia -- 77: Mitral valve stenosis / Shahbudin H Rahimtoola -- 78: Tricuspid valve, pulmonary valve, and multivalvular disease / Pravin M Shah -- 79: Prosthetic heart valves: choice of valve and management of the patient / Shahbudin H Rahimtoola, YingXing Wu, Gary L Grunkemeir, and Albert Starr -- 80: Antithrombotic therapy for valvular heart disease / John H McAnulty and Shahbudin H Rahimtoola --

Part 12: Congenital Heart Disease -- 81: Cardiovascular diseases caused by genetic abnormalities / Ali J Marian, Roman Brugada, and Robert Roberts -- 82: Congenital heart disease in children and adolescents / David R Fulton -- 83: Congenital heart disease in adults / Jamil A Aboulhosn and John S Child -- Part 13: Pericardial Diseases And Endocarditis -- 84: Pericardial disease / Brian D Hoit -- 85: Infective endocarditis / Saptarsi M Haldar and Patrick T O'Gara -- Part 14: Anesthesia, Surgery, And The Heart -- 86: Perioperative evaluation and management of patients with known or suspected cardiovascular disease who undergo noncardiac surgery / Debabrata Mukherjee and Kim A Eagle -- 87: Anesthesia and the patient with cardiovascular disease / David L Reich, Alexander Mittnacht, and Joel A Kaplan -- Part 15: Miscellaneous Conditions And Cardiovascular Disease -- 88: Connective tissue diseases and the cardiovascular system / Jose F Roldan, Robert A O'Rourke, and William C Roberts -- 89: Diagnosis and management of cardiovascular diseases in cancer patients / Edward T H Yeh, Daniel J Lenihan, and Michael S Ewer -- 90: Diabetes and cardiovascular disease / Michael E Farkouh, Elliot J Rayfield, and Valentin Fuster -- 91: Metabolic syndrome, obesity, and diet / Scott M Grundy, Sidney C Smith, Jr -- 92: HIV/AIDS and the cardiovascular system / William Lewis and Peter F Currie -- 93: Effect of noncardiac drugs, electricity, poisons, and radiation on the heart / Andrew L Smith and Wendy M Book -- 94: Adverse cardiovascular drug interactions and complications / Michael D Faulx, Ileana L Pina, and Gary S Francis -- 95: Effects of mood and anxiety disorders on the cardiovascular system / Dominique L Musselman, Monica Kelly Cowles, William M McDonald, and Charles B Nemeroff -- 96: Heart disease and pregnancy / John H McAnulty, Craig S Broberg, and James Metcalfe -- 97: Traumatic heart disease / Panagiotis N Symbas -- 98: Heart and kidney disease / Tahsin Masud and William M McClellan -- 99: Exercise in health and cardiovascular disease / Gerald F Fletcher, Thomas R Flipse, Keith R Oken, and Robert E Safford -- 100: Athlete and the cardiovascular system / N A Mark Estes III, Mark S Link, and Barry J Maron -- 101: Aging and cardiovascular disease in the elderly / Edward G Lakatta, Samer S Najjar, Steven P Schulman, and Gary Gerstenblith -- 102: Women and coronary artery disease / Pamela Charney -- 103: Cardiovascular disease and ethnicity / S Carolina Masri and Anne L Taylor -- 104: Air pollution and heart disease / Robert D Brook, Qinghua Sun, and Sanjay Rajagopalan -- Part 16: Diseases Of The Great Vessels And Peripheral Vessels -- 105: Diseases of the aorta / John A Elefteriades, Jeffrey W Olin, and Jonathan L Halperin -- 106: Cerbrovascular disease and neurologic manifestations of heart disease / Megan C Leary and Louis R Caplan -- 107: Nonsurgical approach to carotid disease / Vivek Rajagopal, Samir R Kapadia, and Jay S Yadav -- 108: Diagnosis and management of diseases of the peripheral arteries and veins / Paul W Wennberg and Thom W Rooke -- 109: Surgical treatment of carotid and peripheral vascular disease / Deepak G Nair and Thomas F Dodson -- 110: Advances in the minimally invasive treatment of peripheral vascular disease / Joaquin Solis, Anjan Gupta, and Tanvir K Bajwa -- Part 17: Social Issues And Cardiovascular Disease -- 111: Cost-effective strategies in cardiology / William S Weintraub and Harlan M Krumholz -- 112: Insurance issues in patients with heart disease / Michael B Clark and William T Friedewald -- 113: Behavioral cardiology treatment approaches to heart disease / Nina Rieckmann, Karina W Davidson, Lynn Clemow, Daichi Shiambo, and Thomas G Pickering -- 114: Complementary and alternative medical therapy in cardiovascular care / Mitchell W Krucoff, Rebecca Costello, Daniel Mark, and John H K Vogel -- 115: Social and societal issues of heart disease / Robert De Vogli and Michael Marmot -- Index.